癌症化疗不会增强正常血液单核细胞中与多药耐药相关的170kd糖蛋白的表达。
Cancer chemotherapy does not enhance MDR-associated 170 kd glycoprotein expression in normal blood mononuclear cells.
作者信息
Geromin A, Michieli M, Damiani D, Michelutti A, Vigevani E, Signor M, Fanin R, Baccarani M
机构信息
Cattedra di Ematologia, Università di Udine, Italy.
出版信息
Haematologica. 1992 Nov-Dec;77(6):470-2.
BACKGROUND
The multidrug resistance (MDR) associated 170kd glycoprotein (P170) is expressed at a low level in normal and malignant cells, but in the latter it becomes frequently overexpressed after chemotherapy. This study evaluated P170 expression in normal blood mononuclear cells after and during cancer chemotherapy.
METHODS
P170 was detected by immunocytochemistry with two monoclonal antibodies (MRK-16 and JSB-1).
RESULTS
P170 expression was low in all samples before, during and after chemotherapy.
CONCLUSIONS
Cancer chemotherapy did not enhance P170 expression in normal peripheral blood mononuclear cells. The mechanisms enhancing P170 expression are likely to be more operative in tumor cells than in normal cells.
背景
多药耐药（MDR）相关的170kd糖蛋白（P170）在正常细胞和恶性细胞中表达水平较低，但在恶性细胞中，化疗后其表达常上调。本研究评估了癌症化疗期间及化疗后正常血液单核细胞中P170的表达情况。
方法
采用两种单克隆抗体（MRK-16和JSB-1）通过免疫细胞化学法检测P170。
结果
化疗前、化疗期间及化疗后所有样本中P170表达均较低。
结论
癌症化疗未增强正常外周血单核细胞中P170的表达。增强P170表达的机制在肿瘤细胞中可能比在正常细胞中更起作用。
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