脊髓灰质炎病毒抗原嵌合体

Poliovirus antigen chimeras.

作者信息

Rose C S, Evans D J

机构信息

Department of Microbiology, University of Reading, Whiteknights, UK.

出版信息

Trends Biotechnol. 1991 Dec;9(12):415-21. doi: 10.1016/0167-7799(91)90142-5.

DOI:10.1016/0167-7799(91)90142-5

PMID:1369352

Abstract

Poliovirus, the aetiological agent of paralytic poliomyelitis, is arguably the best characterized of all animal viruses. Using recombinant-DNA technology, this information, together with the availability of infectious cDNA clones of the notably safe and efficacious live attenuated Sabin 1 vaccine strains of poliovirus, has enabled the creation of hybrid viruses (chimeras) possessing novel antigenicity. The potential applications of these 'epitope-presentation systems' include their use as immunogens, as antigens for serodiagnosis, and as vaccines.

摘要

脊髓灰质炎病毒是麻痹性脊髓灰质炎的病原体，堪称所有动物病毒中特征最为明确的一种。利用重组DNA技术，这些信息以及脊髓灰质炎病毒显著安全有效的减毒活疫苗株沙宾1型的感染性cDNA克隆的可得性，使得具有新抗原性的杂交病毒（嵌合体）得以构建。这些“表位呈递系统”的潜在应用包括用作免疫原、血清诊断抗原和疫苗。