伯氏疏螺旋体鞭毛蛋白上的预后性B细胞表位
Prognostic B-cell epitopes on the flagellar protein of Borrelia burgdorferi.
作者信息
Schneider T, Lange R, Rönspeck W, Weigelt W, Kölmel H W
机构信息
Freie Universität Berlin, Rudolf Virchow Krankenhaus, Neurologie, Germany.
出版信息
Infect Immun. 1992 Jan;60(1):316-9. doi: 10.1128/iai.60.1.316-319.1992.
Abstract
Overlapping decapeptides based on the flagellin sequence of Borrelia burgdorferi B31 (G. S. Gassmann, M. Kramer, U. B. Göbel, and R. Wallich, Nucleic Acids Res. 17:3590, 1989) were used to identify immunologically reactive regions of flagellin. Five serum specimens from patients with late manifestations of Lyme disease and borrelia-specific monoclonal antibody H9724 reacted with an epitope in the central region of the flagellar protein (amino acids 205 to 226), which is heterologous to the amino acid sequences of other bacterial flagellins. This epitope was not recognized by human sera with antibodies to Treponema pallidum, sera of healthy individuals, or sera from patients with stage I or II of Lyme disease.
摘要
基于伯氏疏螺旋体B31鞭毛蛋白序列的重叠十肽（G. S. 加斯曼、M. 克莱默、U. B. 戈贝尔和R. 瓦利希，《核酸研究》17:3590，1989年）被用于鉴定鞭毛蛋白的免疫反应区域。来自莱姆病晚期患者的五份血清标本以及疏螺旋体特异性单克隆抗体H9724与鞭毛蛋白中央区域（氨基酸2０５至226）的一个表位发生反应，该表位与其他细菌鞭毛蛋白的氨基酸序列不同源。该表位未被针对梅毒螺旋体的人血清、健康个体的血清或莱姆病I期或II期患者的血清识别。
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