体内麦角酸二乙酰胺对P物质的增强作用。
Potentiation of substance P by lysergic acid diethvlamide in vivo.
作者信息
KRIVOY W A
出版信息
Br J Pharmacol Chemother. 1961 Jun;16(3):253-6. doi: 10.1111/j.1476-5381.1961.tb01084.x.
Abstract
In doses of 10 mug/kg or more, lysergic acid diethylamide enhanced the fourth potential (DR IV) of the dorsal root potential complex in the cat. Smaller doses of lysergic acid diethylamide did not in themselves alter the DR IV, but revealed an enhancement of the potential by substance P, which by itself had no effect. 2-Bromolysergic acid diethylamide had no action on the dorsal root potentials, but prevented the actions of lysergic acid diethylamide.
摘要
剂量为10微克/千克或更高时，麦角酸二乙酰胺增强了猫背根电位复合体的第四电位（DR IV）。较小剂量的麦角酸二乙酰胺本身不会改变DR IV，但可揭示P物质对该电位的增强作用，而P物质本身并无作用。2-溴麦角酸二乙酰胺对背根电位无作用，但可阻止麦角酸二乙酰胺的作用。
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