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夸休可尔症中的血清转氨酶和异柠檬酸脱氢酶。

Serum transaminases and isocitric dehydrogenase in kwashiorkor.

作者信息

BARON D N

出版信息

J Clin Pathol. 1960 May;13(3):252-5. doi: 10.1136/jcp.13.3.252.

DOI:10.1136/jcp.13.3.252

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC480062/

Abstract

Serum glutamic oxalacetic transaminase (G-OT), glutamic-pyruvic transaminase (G-PT), and isocitric dehydrogenase (ICD) have been estimated in six groups of subjects, namely, normal British adults, normal Nigerian adults, undernourished Nigerian adults and children, Nigerian children with florid protein malnutrition (kwashiorkor), and cases of protein malnutrition after treatment. The normal range in Nigerian adults was apparently slightly lower than in European adults.A marked increase in serum enzyme activity was found in florid malnutrition, and a slight rise in undernutrition. In all cases serum G-PT showed lesser changes than G-OT and ICD. The causes of these abnormalities are discussed. The increased serum enzyme activity is thought to be derived primarily from the liver and possibly also from voluntary muscle. Estimation of serum enzymes is recommended in the investigation of protein malnutrition.

摘要

已对六组受试者的血清谷氨酸草酰乙酸转氨酶（G-OT）、谷氨酸丙酮酸转氨酶（G-PT）和异柠檬酸脱氢酶（ICD）进行了测定，这六组受试者分别为：正常英国成年人、正常尼日利亚成年人、营养不良的尼日利亚成年人及儿童、患有典型蛋白质营养不良（夸希奥科病）的尼日利亚儿童，以及治疗后的蛋白质营养不良病例。尼日利亚成年人的正常范围明显略低于欧洲成年人。在典型营养不良中发现血清酶活性显著升高，而在营养不足时略有升高。在所有病例中，血清G-PT的变化小于G-OT和ICD。讨论了这些异常情况的原因。血清酶活性升高被认为主要源于肝脏，也可能源于随意肌。建议在蛋白质营养不良的调查中进行血清酶的测定。