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Alkylation as the mechanism by which the hepatotoxic pyrrolizidine alkaloids act on cell nuclei.

作者信息

CULVENOR C C, DANN A T, DICK A T

出版信息

Nature. 1962 Aug 11;195:570-3. doi: 10.1038/195570a0.

DOI:10.1038/195570a0

PMID:13882603

Abstract

摘要

相似文献

Alkylation as the mechanism by which the hepatotoxic pyrrolizidine alkaloids act on cell nuclei.

Nature. 1962 Aug 11;195:570-3. doi: 10.1038/195570a0.

The effect of pyrrolizidine alkaloids on liver enzyme systems.

Biochem Pharmacol. 1960 Jun;3:220-30. doi: 10.1016/0006-2952(60)90110-6.

Variation of liver function in immature fowls and susceptibility to seneciphylline.

J Pathol Bacteriol. 1960 Oct;80:399-403. doi: 10.1002/path.1700800224.

The effects of a Senecio alkaloid (monocrotaline) on human embryo liver in tissue culture.

Br J Cancer. 1960 Dec;14(4):637-46. doi: 10.1038/bjc.1960.70.

Hepatotoxic activity of semi-synthetic analogues of pyrrolizidine alkaloids.

Nature. 1960 Mar 19;185:842-3. doi: 10.1038/185842a0.

Further observations on the subacute and chronic liver changes in rats after a single dose of various pyrrolizidine (Senecio) alkaloids.

J Pathol Bacteriol. 1959 Oct;78:471-82. doi: 10.1002/path.1700780213.

The chronic pathological effects on the liver of the rat of the pyrrolizidine alkaloids heliotrine, lasiocarpine, and their N-oxides.

J Pathol Bacteriol. 1959 Oct;78:483-502. doi: 10.1002/path.1700780215.

Induction of morphological changes in human embryo liver cells by the pyrrolizidine alkaloid lasiocarpine.

Br J Exp Pathol. 1972 Apr;53(2):145-9.

[On the mechanism of hypotensive effects of platyphylline].

Farmakol Toksikol. 1960 Jan-Feb;23:13-7.

The relationship between reactivity of metabolites of pyrrolizidine alkaloids and extrahepatic toxicity.

Proc West Pharmacol Soc. 1999;42:13-6.

引用本文的文献

The Role of Astrocytes in Metabolism and Neurotoxicity of the Pyrrolizidine Alkaloid Monocrotaline, the Main Toxin of Crotalaria retusa.

Front Pharmacol. 2012 Aug 3;3:144. doi: 10.3389/fphar.2012.00144. eCollection 2012.

THE EFFECT OF CYANIDE AND AZIDE ON THE MUTAGENIC ACTIVITY OF THE PYRROLIZIDINE ALKALOID HELIOTRINE IN DROSOPHILA MELANOGASTER.

Z Vererbungsl. 1963 Dec 30;94:331-5. doi: 10.1007/BF00897592.

LIVER DISEASE AND "NATURAL" HEPATOTOXINS.

Bull World Health Organ. 1963;29(6):823-33.

Physicochemical and metabolic basis for the differing neurotoxicity of the pyrrolizidine alkaloids, trichodesmine and monocrotaline.

Neurochem Res. 1996 Feb;21(2):141-6. doi: 10.1007/BF02529131.

In vivo metabolism of retrorsine and retrorsine-N-oxide.

Arch Toxicol. 1993;67(1):39-43. doi: 10.1007/BF02072033.

The development of the hepatic megalocytosis of chronic pyrrolizidine alkaloid poisoning.

Am J Pathol. 1969 Sep;56(3):405-21.

The effect of heliotrine, a pyrrolizidine alkaloid, on human liver cells in culture.

Br J Exp Pathol. 1969 Aug;50(4):361-70.

Effects of the hepatotoxic agents retrorsine and aflatoxin B1 on hepatic protein synthesis in the rat.

Biochem J. 1968 Aug;109(1):87-91. doi: 10.1042/bj1090087.

Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum.

Br J Pharmacol. 1971 Apr;41(4):683-90. doi: 10.1111/j.1476-5381.1971.tb07076.x.

Case report. Ragwort toxicosis in a heifer.

Can Vet J. 1969 Nov;10(11):302-6.

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Alkylation as the mechanism by which the hepatotoxic pyrrolizidine alkaloids act on cell nuclei.

作者信息

CULVENOR C C, DANN A T, DICK A T

出版信息

Nature. 1962 Aug 11;195:570-3. doi: 10.1038/195570a0.

DOI:10.1038/195570a0

PMID:13882603

Abstract

摘要

相似文献

Alkylation as the mechanism by which the hepatotoxic pyrrolizidine alkaloids act on cell nuclei.

Nature. 1962 Aug 11;195:570-3. doi: 10.1038/195570a0.

The effect of pyrrolizidine alkaloids on liver enzyme systems.

Biochem Pharmacol. 1960 Jun;3:220-30. doi: 10.1016/0006-2952(60)90110-6.

Variation of liver function in immature fowls and susceptibility to seneciphylline.

J Pathol Bacteriol. 1960 Oct;80:399-403. doi: 10.1002/path.1700800224.

The effects of a Senecio alkaloid (monocrotaline) on human embryo liver in tissue culture.

Br J Cancer. 1960 Dec;14(4):637-46. doi: 10.1038/bjc.1960.70.

Hepatotoxic activity of semi-synthetic analogues of pyrrolizidine alkaloids.

Nature. 1960 Mar 19;185:842-3. doi: 10.1038/185842a0.

Further observations on the subacute and chronic liver changes in rats after a single dose of various pyrrolizidine (Senecio) alkaloids.

J Pathol Bacteriol. 1959 Oct;78:471-82. doi: 10.1002/path.1700780213.

The chronic pathological effects on the liver of the rat of the pyrrolizidine alkaloids heliotrine, lasiocarpine, and their N-oxides.

J Pathol Bacteriol. 1959 Oct;78:483-502. doi: 10.1002/path.1700780215.

Induction of morphological changes in human embryo liver cells by the pyrrolizidine alkaloid lasiocarpine.

Br J Exp Pathol. 1972 Apr;53(2):145-9.

[On the mechanism of hypotensive effects of platyphylline].

Farmakol Toksikol. 1960 Jan-Feb;23:13-7.

The relationship between reactivity of metabolites of pyrrolizidine alkaloids and extrahepatic toxicity.

Proc West Pharmacol Soc. 1999;42:13-6.

引用本文的文献

The Role of Astrocytes in Metabolism and Neurotoxicity of the Pyrrolizidine Alkaloid Monocrotaline, the Main Toxin of Crotalaria retusa.

Front Pharmacol. 2012 Aug 3;3:144. doi: 10.3389/fphar.2012.00144. eCollection 2012.

THE EFFECT OF CYANIDE AND AZIDE ON THE MUTAGENIC ACTIVITY OF THE PYRROLIZIDINE ALKALOID HELIOTRINE IN DROSOPHILA MELANOGASTER.

Z Vererbungsl. 1963 Dec 30;94:331-5. doi: 10.1007/BF00897592.

LIVER DISEASE AND "NATURAL" HEPATOTOXINS.

Bull World Health Organ. 1963;29(6):823-33.

Physicochemical and metabolic basis for the differing neurotoxicity of the pyrrolizidine alkaloids, trichodesmine and monocrotaline.

Neurochem Res. 1996 Feb;21(2):141-6. doi: 10.1007/BF02529131.

In vivo metabolism of retrorsine and retrorsine-N-oxide.

Arch Toxicol. 1993;67(1):39-43. doi: 10.1007/BF02072033.

The development of the hepatic megalocytosis of chronic pyrrolizidine alkaloid poisoning.

Am J Pathol. 1969 Sep;56(3):405-21.

The effect of heliotrine, a pyrrolizidine alkaloid, on human liver cells in culture.

Br J Exp Pathol. 1969 Aug;50(4):361-70.

Effects of the hepatotoxic agents retrorsine and aflatoxin B1 on hepatic protein synthesis in the rat.

Biochem J. 1968 Aug;109(1):87-91. doi: 10.1042/bj1090087.

Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum.

Br J Pharmacol. 1971 Apr;41(4):683-90. doi: 10.1111/j.1476-5381.1971.tb07076.x.

Case report. Ragwort toxicosis in a heifer.

Can Vet J. 1969 Nov;10(11):302-6.