[慢性实验性应激和内源性阿片类物质对甲状腺组织生理参数的影响]

[Effects of chronic experimental stress and endogenous opioids on histophysiological parameters of the thyroid gland].

作者信息

Krasnoperov R A, Glumova V A, Riashchikov S N, Proshutina N E

出版信息

Biull Eksp Biol Med. 1992 Jan;113(1):33-5.

Abstract

In adult rabbits stress was modelled by electrostimulation of the hypothalamus ventromedial nucleus (15-hour-long session during 30 days) and medulla's raphe big nucleus which is one of the central places of the opioid peptides synthesis was irritated. It is revealed, that under stress thyroid gland responds by serum T3 increase in comparison with control animals with statistically significant variability of the T4 profile. Chronicity of the emotional agitation involves destructive changes in the thyroid parenchyma the hurting effect of the negative emotional factor is expressed less during opioid peptides complex activation. It is suggested that there are its own stress-limiting mechanisms in thyroid gland.

摘要

在成年兔中，通过电刺激下丘脑腹内侧核（持续30天，每次15小时）来模拟应激，并且刺激延髓中缝大核，它是阿片肽合成的主要部位之一。结果显示，与对照动物相比，应激状态下甲状腺的反应是血清T3升高，T4水平具有统计学意义的显著变化。情绪激动的慢性化会导致甲状腺实质的破坏性改变，在阿片肽复合物激活期间，负面情绪因素的伤害作用表现得较小。提示甲状腺存在自身的应激限制机制。