兔染色体的新基因定位；对染色体进化的启示。

New gene assignments to rabbit chromosomes; implications for chromosome evolution.

作者信息

Lemieux N, Dutrillaux B

机构信息

URA 620 CNRS, Institut Curie Section de Biologie, Paris, France.

出版信息

Cytogenet Cell Genet. 1992;61(2):132-4. doi: 10.1159/000133390.

DOI:10.1159/000133390

PMID:1395722

Abstract

The genes for SOD1 and SOD2 (superoxide dismutases 1 and 2), RB1 (retinoblastoma), TYMS (thymidylate synthase), and TK1 (thymidine kinase) were mapped by in situ hybridization using biotinylated probes to rabbit chromosomes 6, 12, 8, 9, and 19, respectively. This confirms their proposed homoeologies with human chromosomes 21, 6, 13, 18, and 17, respectively, and provides additional information on the modification of these chromosomes during evolution.

摘要

利用生物素化探针，通过原位杂交分别将超氧化物歧化酶1（SOD1）、超氧化物歧化酶2（SOD2）、视网膜母细胞瘤（RB1）、胸苷酸合成酶（TYMS）和胸苷激酶（TK1）的基因定位到兔的6号、12号、8号、9号和19号染色体上。这分别证实了它们与人类21号、6号、13号、18号和17号染色体推测的同源性，并提供了有关这些染色体在进化过程中修饰的更多信息。