凝聚相中硫酸乙酰肝素钠的分子构象。
Molecular conformation of sodium heparan sulphate in the condensed phase.
作者信息
Elloway H F, Atkins E D
出版信息
Biochem J. 1977 Mar 1;161(3):495-8. doi: 10.1042/bj1610495.
Abstract
By using the X-ray-diffraction results reported previously for sodium heparan sulphate, a twofold helical conformation with an axially projected disaccharide repeat (h) equal to 0.93 nm has been examined in detail. On the basis of a repeating sequence of 1,4-alpha-D-glucosamine and 1,4-beta-D-glucuronic acid, trial and stereochemically feasible molecular models were computer-generated. An optimum twofold helical conformation is proposed, incorporating stabilizing intra-chain hydrogen bonds across both glycosidic linkages.
摘要
利用先前报道的硫酸乙酰肝素钠的X射线衍射结果，详细研究了轴向投影二糖重复单元（h）等于0.93nm的双螺旋构象。基于1,4-α-D-葡糖胺和1,4-β-D-葡糖醛酸的重复序列，通过计算机生成了试验性的、立体化学上可行的分子模型。提出了一种最佳的双螺旋构象，其中包含跨越两个糖苷键的稳定链内氢键。
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