从红青霉培养物中提取肝毒性物质并进行初步表征。
Extraction and preliminary characterization of a hepatotoxic substance from cultures of Penicillium rubrum.
作者信息
WILSON B J, WILSON C H
出版信息
J Bacteriol. 1962 Aug;84(2):283-90. doi: 10.1128/jb.84.2.283-290.1962.
Abstract
Wilson, Benjamin J. (David Lipscomb College, Nashville, Tenn.) and Christina H. Wilson. Extraction and preliminary characterization of a hepatotoxic substance from cultures of Penicillium rubrum. J. Bacteriol. 84:283-290. 1962.-A toxic acidic substance was extracted from cultures of Penicillium rubrum P-13 grown on corn-sucrose medium. Administration to mice, guinea pigs, rabbits, and dogs produced hepatotoxic and hemorrhagic syndromes. These findings were similar to those previously reported in which livestock were fed feedstuff infected with pure cultures of the fungus. Preliminary studies were made of the physical and chemical properties of the toxic material.
摘要
威尔逊，本杰明·J.（田纳西州纳什维尔市大卫·利普斯科姆学院）和克里斯蒂娜·H.威尔逊。从红青霉培养物中提取一种肝毒性物质并进行初步表征。《细菌学杂志》84:283 - 290。1962年。——从在玉米 - 蔗糖培养基上生长的红青霉P - 13培养物中提取出一种有毒酸性物质。给小鼠、豚鼠、兔子和狗注射该物质会产生肝毒性和出血综合征。这些发现与之前报道的给家畜喂食感染该真菌纯培养物的饲料的情况相似。对该有毒物质的物理和化学性质进行了初步研究。
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