KAUFMAN H E, HEIDELBERGER C
Science. 1964 Aug 7;145(3632):585-6. doi: 10.1126/science.145.3632.585.
5-Trifluoromethyl-2'-deoxyuridine (F(3)TDR) has potent therapeutic antiviral activity in herpes simplex infection of the rabbit cornea with strains of herpes virus both sensitive and resistant to 5-iodo-2'-deoxyuridine, and in corneal infection with vaccinia. 5-Trifluoromethyl uracil is not therapeutically active in herpetic keratitis.
5-三氟甲基-2'-脱氧尿苷（F(3)TDR）对感染了对5-碘-2'-脱氧尿苷敏感和耐药的疱疹病毒株的兔角膜单纯疱疹感染以及痘苗角膜感染具有强大的治疗性抗病毒活性。5-三氟甲基尿嘧啶在疱疹性角膜炎中没有治疗活性。
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