衰老的F344大鼠内分泌胰腺的去甲肾上腺素敏感性

Norepinephrine sensitivity of the endocrine pancreas in aging F344 rats.

作者信息

McDonald R B, Herrmann S, Curry D L

机构信息

Department of Nutrition, University of California, Davis 95616.

出版信息

Aging (Milano). 1992 Sep;4(3):227-30. doi: 10.1007/BF03324096.

DOI:10.1007/BF03324096

PMID:1420406

Abstract

The effect of norepinephrine (NE) infusion on glucose-stimulated insulin secretion was evaluated in whole perfused pancreases isolated from 6-, 12-, and 26-month-old male Fischer 344 (F344) rats. Glucose-stimulated insulin secretion was significantly inhibited by NE in all age groups. There was no significant effect of aging on the sensitivity or magnitude of inhibition at any of the concentrations of NE. In contrast, vascular pressure attained during NE infusion was significantly less in the 26-month-old rats compared to 6- and 12-month-old animals. These results suggest that the adrenoceptor neuroeffector mechanism of the smooth muscle declines at a faster age-related rate than does the beta-cell's adrenoceptor mechanism.

摘要

在从6个月、12个月和26个月大的雄性费希尔344（F344）大鼠分离出的全胰腺灌注实验中，评估了去甲肾上腺素（NE）输注对葡萄糖刺激的胰岛素分泌的影响。在所有年龄组中，NE均显著抑制葡萄糖刺激的胰岛素分泌。在任何NE浓度下，衰老对抑制敏感性或抑制程度均无显著影响。相比之下，与6个月和12个月大的动物相比，26个月大的大鼠在NE输注期间达到的血管压力显著更低。这些结果表明，平滑肌的肾上腺素能受体神经效应机制比β细胞的肾上腺素能受体机制以更快的与年龄相关的速度衰退。