与“脱髓鞘疾病”相关的培养脑组织的功能研究
FUNCTIONAL STUDIES OF CULTURED BRAIN TISSUES AS RELATED TO "DEMYELINATIVE DISORDERS".
作者信息
BORNSTEIN M B, CRAIN S M
出版信息
Science. 1965 May 28;148(3674):1242-4. doi: 10.1126/science.148.3674.1242.
Abstract
The serums from animals with experimental allergic encephalomyelitis and humans with multiple sclerosis produce, in addition to demyelination, rapid, reversible alterations in complex, evoked bioelectric (synaptic) responses of cultured cerebral cortex and spinal cord tissues of the mouse. The active factors are dependent on complement and are not present in serums from normal animals and humans.
摘要
患有实验性变应性脑脊髓炎的动物血清以及患有多发性硬化症的人类血清，除了会导致脱髓鞘外，还会使小鼠培养的大脑皮层和脊髓组织的复杂诱发生物电（突触）反应迅速发生可逆性改变。这些活性因子依赖补体，正常动物和人类的血清中不存在这些因子。
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