WEHRLE P F
Calif Med. 1965 Aug;103(2):79-86.
Means are now at hand, if properly employed, to virtually eliminate clinical poliomyelitis and measles from this country. If such control is to be accomplished, more effective means are required to reach virtually all of the four million infants born each year in this country. Influenza can be suppressed, and improvements in influenza vaccine have been achieved in recent years. It seems likely at this time that at least several of the more important viral diseases can be controlled by utilizing antigens based on the biologic characteristics of the agent, and directed toward the reservoir of infection and the conditions favoring transmission of the infection. The theoretical problem of the effects in man of viruses that are oncogenic in rodents and are derived from various tissue culture systems deserves serious attention. However, this consideration, that of antigenic potency, and other problems reviewed should not be allowed to subvert efforts to solve the real problems that face us, the disability and death resulting from these common infections.
现在已有办法,如果运用得当,实际上可以在本国消除临床脊髓灰质炎和麻疹。要实现这种控制,就需要更有效的手段来覆盖本国每年出生的近四百万婴儿。流感可以得到抑制,近年来流感疫苗也有了改进。目前看来,至少几种更重要的病毒性疾病可以通过利用基于病原体生物学特性的抗原加以控制,这些抗原针对感染源以及有利于感染传播的条件。啮齿动物致癌且源自各种组织培养系统的病毒对人类影响的理论问题值得认真关注。然而,这种考虑、抗原效力问题以及所审查的其他问题,都不应妨碍我们为解决实际面临的问题——这些常见感染导致的残疾和死亡——而做出的努力。