肺癌延迟诊断与侵袭程度及生存之间的关系。

Relationship between delayed diagnosis and the degree of invasion and survival in lung cancer.

作者信息

Pita-Fernández Salvador, Montero-Martinez Carmen, Pértega-Diaz Sonia, Verea-Hernando Hector

机构信息

Clinical Epidemiology and Biostatistics Unit, Complexo Hospitalario Universitario Juan Canalejo, Hotel de Pacientes 7a Planta, As Xubias de Arriba 84, 15006 A Coruña, Spain.

出版信息

J Clin Epidemiol. 2003 Sep;56(9):820-5. doi: 10.1016/s0895-4356(03)00166-5.

DOI:10.1016/s0895-4356(03)00166-5

PMID:14505765

Abstract

BACKGROUND AND OBJECTIVES

The aim of this study is to evaluate the relationship between the interval from first symptom to diagnosis (SDI) and the degree of invasion and survival in lung cancer.

METHODS

Three hundred seventy-eight patients with lung cancer were included. SDI was defined as the time calculated from the cytohistologic confirmation of the diagnosis of cancer and the first symptoms noted by the patient and attributed to cancer by the physician. The degree of invasion was determined by TNM classification.

RESULTS

The median SDI was 2.1 months, and did not correlate with stage. Survival decreased progressively according to TNM classification. Adjusting for age, sex, SDI and TNM, survival was influenced by age (RR=1.02) and by staging [Stage (Ib) RR=1.3; stage (IIIa) RR=2.6; stage (IIIb) RR=4.06; stage (IV) RR=7.5]. SDI was not found to affect survival (RR=1.01; 95% CI: 0.94-1.08). In the small cell group, SDI also failed to modify survival.

CONCLUSIONS

The results of this study indicate that SDI has no effect on the stage or survival of patients with lung cancer.

摘要

背景与目的

本研究旨在评估肺癌患者从首次出现症状到确诊的时间间隔（SDI）与侵袭程度及生存率之间的关系。

方法

纳入378例肺癌患者。SDI定义为从癌症诊断的细胞组织学确认到患者首次出现症状且医生将其归因于癌症所计算出的时间。侵袭程度由TNM分类确定。

结果

SDI的中位数为2.1个月，且与分期无关。根据TNM分类，生存率逐渐降低。在对年龄、性别、SDI和TNM进行校正后，生存率受年龄（风险比[RR]=1.02）和分期影响[（Ib）期RR=1.3；（IIIa）期RR=2.6；（IIIb）期RR=4.06；（IV）期RR=7.5]。未发现SDI影响生存率（RR=1.01；95%置信区间：0.94 - 1.08）。在小细胞组中，SDI也未改变生存率。