引发毒力因子以便递送至宿主。

Priming virulence factors for delivery into the host.

作者信息

Stebbins C Erec, Galán Jorge E

机构信息

Laboratory of Structural Microbiology, The Rockefeller University, Box 52, 1230 York Avenue, New York, New York 10021, USA.

出版信息

Nat Rev Mol Cell Biol. 2003 Sep;4(9):738-43. doi: 10.1038/nrm1201.

DOI:10.1038/nrm1201

PMID:14506477

Abstract

Several medically important Gram-negative bacterial pathogens inject virulence factors into host cells through a type III secretion system and specialized bacterial chaperones are required for their effective delivery. Recent structural work shows that these chaperones maintain virulence factors in a partially non-globular conformation that is primed for unfolding and translocation through the 'injectisome'.

摘要

几种具有重要医学意义的革兰氏阴性细菌病原体通过III型分泌系统将毒力因子注入宿主细胞，而其有效递送需要特殊的细菌伴侣蛋白。最近的结构研究表明，这些伴侣蛋白使毒力因子维持在部分非球状构象，这种构象易于通过“注射体”展开和转运。