PPARγ基因中脯氨酸至丙氨酸密码子12多态性与2型糖尿病关联的前瞻性研究。
Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes.
作者信息
Memisoglu Asli, Hu Frank B, Hankinson Susan E, Liu Simin, Meigs James B, Altshuler David M, Hunter David J, Manson JoAnn E
机构信息
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
出版信息
Diabetes Care. 2003 Oct;26(10):2915-7. doi: 10.2337/diacare.26.10.2915.
OBJECTIVE
To determine whether the Pro12Ala polymorphism in the PPARgamma gene was associated with risk of type 2 diabetes in the Nurses' Health Study.
RESEARCH DESIGN AND METHODS
The study was a nested case-control study of 387 incident cases of type 2 diabetes and 771 matching control subjects nested within the Nurses' Health Study, a prospective cohort study. Association between PPARgamma genotype and incident type 2 diabetes was estimated using logistic regression.
RESULTS
Carriers of the PPARgamma variant 12Ala allele had reduced risk of type 2 diabetes compared with noncarriers. Unadjusted and adjusted odds ratios of type 2 diabetes were 0.74 (95% CI 0.55-1.00) and 0.72 (0.52-0.99), respectively.
CONCLUSIONS
The results of this study provide further support for an inverse association between the PPARgamma variant 12Ala allele and risk of type 2 diabetes.
目的
在护士健康研究中确定PPARγ基因Pro12Ala多态性是否与2型糖尿病风险相关。
研究设计与方法
本研究是一项巢式病例对照研究，在护士健康研究（一项前瞻性队列研究）中纳入了387例2型糖尿病新发病例和771例匹配的对照对象。使用逻辑回归估计PPARγ基因型与2型糖尿病发病之间的关联。
结果
与非携带者相比，PPARγ变异体12Ala等位基因携带者患2型糖尿病的风险降低。2型糖尿病未经调整和调整后的优势比分别为0.74（95%CI 0.55 - 1.00）和0.72（0.52 - 0.99）。
结论
本研究结果为PPARγ变异体12Ala等位基因与2型糖尿病风险之间的负相关提供了进一步支持。
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