壮观霉素修饰。III. 氯代脱氧类似物。

Spectinomycin modification. III Chloro-deoxy analogs.

作者信息

Carney R E, Rosenbrook W

出版信息

J Antibiot (Tokyo). 1977 Nov;30(11):960-4. doi: 10.7164/antibiotics.30.960.

DOI:10.7164/antibiotics.30.960

Abstract

9-Epichloro-9-deoxy-4(R)-dihydrospectinomycin (3), 9-chloro-9-deoxy-4(R)-dihydrospectinomycin (7), 9-deoxy-8, 9-epimino-4(R)-dihydrospectinomycin (6), and 9-epichloro-9-deoxy-spectinomycin (10) have been prepared and their structures established by proton magnetic resonance. These analogs are devoid of antibiotic activity.

摘要

9-表氯-9-脱氧-4(R)-二氢壮观霉素(3)、9-氯-9-脱氧-4(R)-二氢壮观霉素(7)、9-脱氧-8,9-表亚氨基-4(R)-二氢壮观霉素(6)和9-表氯-9-脱氧壮观霉素(10)已被制备出来，并且它们的结构通过质子磁共振得以确定。这些类似物没有抗生素活性。