Auvin Stéphane, Dalle Jean-Hugues, Ganga-Zandzou Patrice-Serge, Ythier Hubert
Department of Pediatrics, Faculty of Medicine and Children's Hospital, Lille, France.
Pediatr Hematol Oncol. 2003 Dec;20(8):611-5.
A patient developed agranulocytosis after Epstein-Barr infection. Bone marrow examination revealed normal myelopoiesis with reduced mature neutrophil polymorphonuclear cells. IgG-specific antineutrophil antibodies (anti-HNA-1a) were found in serum and on polymorphonuclear cells, suggesting that the agranulocytosis after infectious mononucleosis was caused by an autoimmune mechanism.
一名患者在感染爱泼斯坦-巴尔病毒后出现粒细胞缺乏症。骨髓检查显示骨髓造血正常,但成熟的中性粒细胞多形核细胞减少。在血清和多形核细胞上发现了IgG特异性抗中性粒细胞抗体(抗HNA-1a),提示传染性单核细胞增多症后的粒细胞缺乏症是由自身免疫机制引起的。