Oku Takatomi, Yoshizaki Naohito, Waga Eriko, Sumiyoshi Tetsuya, Ohira Noriaki, Nishihori Yasuki, Ohi Motoh, Kondo Hitoshi, Motohara Toshitsugu, Yoshida Yuji
Dept. of Gastroenterology, Tonan Hospital.
Gan To Kagaku Ryoho. 2003 Oct;30(10):1515-8.
The patient was a 68-year-old woman who visited a nearby clinic with a chief complaint of right hypochondrial pain. A mass lesion in the gallbladder was found by ultrasonography. She was referred to our hospital for further examination and was diagnosed with gallbladder cancer. Cholecystectomy and bile duct resection were performed. Six months after the surgery, multiple liver metastases were found. A subcutaneous implant reservoir was placed in the hepatic artery from the right femoral artery. After arterial infusion chemotherapy by 5-FU and CDDP, or 5-FU alone, liver metastasis markedly responded and became undetectable, and therapy was therefore discontinued. The patient has been disease-free without any sign of recurrence for 7 months after CR was achieved. It is suggested that arterial infusion chemotherapy is useful and safe for the treatment of liver metastasis from gallbladder cancer.
该患者为一名68岁女性,因右季肋部疼痛为主诉前往附近诊所就诊。超声检查发现胆囊有占位性病变。她被转诊至我院进行进一步检查,被诊断为胆囊癌。实施了胆囊切除术和胆管切除术。术后6个月,发现多发肝转移。经右股动脉在肝动脉置入皮下植入式储液器。在经肝动脉灌注5-氟尿嘧啶和顺铂或仅灌注5-氟尿嘧啶化疗后,肝转移明显缓解且无法检测到,因此停止治疗。达到完全缓解后7个月,患者无疾病迹象且未复发。提示动脉灌注化疗对胆囊癌肝转移的治疗是有效且安全的。