疾病中的肠道：生理要素及其临床意义。
Gut in diseases: physiological elements and their clinical significance.
作者信息
Ding Lian-An, Li Jie-Shou
机构信息
Department of General Surgery, Affilitated Hospital of Medical School, Qingdao University, Qingdao 266003, Shandong Province, China.
出版信息
World J Gastroenterol. 2003 Nov;9(11):2385-9. doi: 10.3748/wjg.v9.i11.2385.
Abstract
The intestinal barrier function of GI tract is very important in the body except for the function of digestion and absorption. The functional status of gut barrier basically reflects the stress severity when body suffers from trauma and various stimulations. Many harmful factors such as drugs, illnesses, trauma and burns can damage the gut barrier, which can lead to the barrier dysfunction and bacterial/endotoxin translocation. The paper discusses and reviews the concepts, anatomy, pathophysiology of gut barrier and its clinical relations.
摘要
胃肠道的肠道屏障功能在人体中非常重要，除了消化和吸收功能外。肠道屏障的功能状态基本反映了身体遭受创伤和各种刺激时的应激严重程度。许多有害因素，如药物、疾病、创伤和烧伤，都可能损害肠道屏障，进而导致屏障功能障碍以及细菌/内毒素移位。本文对肠道屏障的概念、解剖结构、病理生理学及其临床关系进行了讨论和综述。
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本文引用的文献
1
The anabolic effects of recombinant human growth hormone and glutamine on parenterally fed, short bowel rats.
World J Gastroenterol. 2002 Aug;8(4):752-7. doi: 10.3748/wjg.v8.i4.752.
2
Lipopolysaccharide-induced enterocyte-derived nitric oxide induces intestinal monolayer permeability in an autocrine fashion.
Shock. 2002 Mar;17(3):180-4. doi: 10.1097/00024382-200203000-00004.
3
Preventive effect of glutamine on intestinal barrier dysfunction induced by severe trauma.
World J Gastroenterol. 2002 Feb;8(1):168-71. doi: 10.3748/wjg.v8.i1.168.
4
Effect of bowel rehabilitative therapy on structural adaptation of remnant small intestine: animal experiment.
World J Gastroenterol. 2001 Feb;7(1):66-73. doi: 10.3748/wjg.v7.i1.66.
5
Growth hormone stimulates remnant small bowel epithelial cell proliferation.
World J Gastroenterol. 2000 Dec;6(6):909-913. doi: 10.3748/wjg.v6.i6.909.
6
Epidermal growth factor prevents gut atrophy and maintains intestinal integrity in rats with acute pancreatitis.
World J Gastroenterol. 2000 Oct;6(5):762-765. doi: 10.3748/wjg.v6.i5.762.
7
Surgical stress induces phospholipid degradation in the intestinal brush border membrane.
J Surg Res. 2000 Dec;94(2):178-84. doi: 10.1006/jsre.2000.6007.
8
Glutamine-enriched total parenteral nutrition maintains intestinal interleukin-4 and mucosal immunoglobulin A levels.
JPEN J Parenter Enteral Nutr. 2000 Sep-Oct;24(5):270-4; discussion 274-5. doi: 10.1177/0148607100024005270.
9
Individual neuropeptides regulate gut-associated lymphoid tissue integrity, intestinal immunoglobulin A levels, and respiratory antibacterial immunity.
JPEN J Parenter Enteral Nutr. 2000 Sep-Oct;24(5):261-8; discussion 268-9. doi: 10.1177/0148607100024005261.
10
Increased gut permeability and bacterial translocation in Pseudomonas pneumonia-induced sepsis.
Crit Care Med. 2000 Jul;28(7):2573-7. doi: 10.1097/00003246-200007000-00065.
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