Multidrug regimens in moderate & severe hypertension.

We have briefly discussed the antihypertensive drug interactions which result in additive or synergistic actions on lowering of blood pressure when they are administered concomitantly. The choice of antihypertensive agents should be individualized based on the patient's age, race, sex, weight prior therapy, coexisting diseases, underlying diseases, and the pathophysiology of the disease. The goal of antihypertensive treatment extends not only to the control of hypertension per se but also to the reduction of side effect profiles, the treatment of co-existing diseases and optimizing quality of life.