一种测量局部通气和灌注的新型定量单光子发射计算机断层扫描（SPECT）方法的生理学评估
Physiological evaluation of a new quantitative SPECT method measuring regional ventilation and perfusion.
作者信息
Petersson Johan, Sánchez-Crespo Alejandro, Rohdin Malin, Montmerle Stéphanie, Nyrén Sven, Jacobsson Hans, Larsson Stig A, Lindahl Sten G E, Linnarsson Dag, Glenny Robb W, Mure Margareta
机构信息
Department of Anesthesiology and Intensive Care, Karolinska Hospital, Stockholm, Sweden.
出版信息
J Appl Physiol (1985). 2004 Mar;96(3):1127-36. doi: 10.1152/japplphysiol.00092.2003. Epub 2003 Nov 14.
We have developed a new quantitative single-photon-emission computed tomography (SPECT) method that uses (113m)In-labeled albumin macroaggregates and Technegas ((99m)Tc) to estimate the distributions of regional ventilation and perfusion for the whole lung. The multiple inert-gas elimination technique (MIGET) and whole lung respiratory gas exchange were used as physiological evaluations of the SPECT method. Regional ventilation and perfusion were estimated by SPECT in nine healthy volunteers during awake, spontaneous breathing. Radiotracers were administered with subjects sitting upright, and SPECT images were acquired with subjects supine. Whole lung gas exchange of MIGET gases and arterial Po(2) and Pco(2) gases was predicted from estimates of regional ventilation and perfusion. We found a good agreement between measured and SPECT-predicted exchange of MIGET and respiratory gases. Correlations (r(2)) between SPECT-predicted and measured inert-gas excretions and retentions were 0.99. The method offers a new tool for measuring regional ventilation and perfusion in humans.
我们开发了一种新的定量单光子发射计算机断层扫描（SPECT）方法，该方法使用（113m）铟标记的白蛋白大聚合体和锝气（（99m）锝）来估计全肺区域通气和灌注的分布。多惰性气体排除技术（MIGET）和全肺呼吸气体交换被用作该SPECT方法的生理学评估。在9名健康志愿者清醒、自主呼吸期间，通过SPECT估计区域通气和灌注。放射性示踪剂在受试者直立坐位时给药，SPECT图像在受试者仰卧位时采集。根据区域通气和灌注的估计值预测MIGET气体以及动脉氧分压（Po₂）和二氧化碳分压（Pco₂）气体的全肺气体交换。我们发现MIGET和呼吸气体的测量值与SPECT预测的交换值之间具有良好的一致性。SPECT预测的和测量的惰性气体排泄与潴留之间的相关性（r²）为0.99。该方法为测量人体区域通气和灌注提供了一种新工具。
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