Thioune Oumar, Khouma Barham, Diarra Mounibé, Diop Alioune B, Lô Issa
Laboratoire de Pharmacie Galénique et Législation, Faculté de Médecine, de Pharmacie et d'Odonto-stomatologie-UCAD, Dakar, Sénégal.
J Pharm Belg. 2003;58(3):81-4.
A shea butter ointment containing 3% aureomycin (clortetracyclin hydrocloride) was prepared and some of its macroscopic and microscopic characteristics were evaluated. Then, the release of the active ingredient was compared by UV spectrophotometry with those obtained when excipients such as petroleum jelly and lanoline were used. Results had shown that the shea butter ointment had satisfactory characteristics. In the other hand, it was found that shea butter released the aureomycin easily and at a faster rate than the other excipients.
制备了一种含有3%金霉素(盐酸氯四环素)的乳木果油软膏,并对其一些宏观和微观特性进行了评估。然后,通过紫外分光光度法将活性成分的释放情况与使用凡士林和羊毛脂等赋形剂时获得的情况进行了比较。结果表明,乳木果油软膏具有令人满意的特性。另一方面,发现乳木果油比其他赋形剂更容易且更快地释放金霉素。