Hipgrave David B, Nguyen Thu Van, Vu Minh Huong, Hoang Thuy Long, Do Tuan Dat, Tran Nam Trung, Jolley Damien, Maynard James E, Biggs Beverley-Ann
International Health Unit, The Burnet Institute, Alfred Medical Research & Education Precinct, Melbourne, Australia.
Am J Trop Med Hyg. 2003 Sep;69(3):288-94.
To ascertain hepatitis B virus (HBV) infection rates for Vietnam, we surveyed HBV markers in two districts of Thanh Hoa province. We randomly selected 536 infants (9- < or = 18 months old), 228 children (4 to < or = 6 years old), 219 adolescents (14 to < or = 16 years old), and 596 adults (25 to < or = 40 years old). On questioning, none of those surveyed had received vaccine against HBV. Hepatitis B virus surface antigen (HBsAg) and total HBV core antibody (anti-HBc) were measured in all specimens, and HBV e antigen (HBeAg) in those positive for HBsAg, and HBV surface antibody (anti-HBs) were measured in all others. Current infection (HBsAg+) rates were infants = 12.5%, children = 18.4%, adolescents = 20.5%, and adults = 18.8%. Current or previous infection (HBsAg+, anti-HBc+, or anti-HBs+) increased with age (infants = 19.6%, children = 36.4%, adolescents = 55.3%, adults = 79.2%). Rates of HBeAg among those HBsAg+ were infants = 85.1%, children = 88.1%, adolescents = 71.1%, and adults = 30.4%. The epidemiology of HBV in Vietnam resembles that of many southeast Asian nations before introduction of vaccine. Immunization of newborns will have enormous impact on HBV-related morbidity and mortality there.
为确定越南的乙型肝炎病毒（HBV）感染率，我们在清化省的两个地区对HBV标志物进行了调查。我们随机选取了536名婴儿（9至＜或=18个月大）、228名儿童（4至＜或=6岁）、219名青少年（14至＜或=16岁）和596名成年人（25至＜或=40岁）。经询问，所有被调查者均未接种过HBV疫苗。对所有样本检测乙型肝炎病毒表面抗原（HBsAg）和总HBV核心抗体（抗-HBc），对HBsAg阳性者检测HBV e抗原（HBeAg），对其他所有人检测HBV表面抗体（抗-HBs）。现感染（HBsAg+）率分别为：婴儿12.5%、儿童18.4%、青少年20.5%、成年人18.8%。现感染或既往感染（HBsAg+、抗-HBc+或抗-HBs+）率随年龄增长而升高（婴儿19.6%、儿童36.4%、青少年55.3%、成年人79.2%）。HBsAg阳性者中HBeAg率分别为：婴儿85.1%、儿童88.1%、青少年71.1%、成年人30.4%。越南HBV的流行病学情况与许多东南亚国家在疫苗引入前相似。新生儿免疫接种将对该国与HBV相关的发病率和死亡率产生巨大影响。
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