利奈唑胺在耐甲氧西林葡萄球菌感染的骨与关节组织中的渗透情况。
Linezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci.
作者信息
Kutscha-Lissberg Friedrich, Hebler Ute, Muhr Gert, Köller Manfred
机构信息
Department of Surgery-Trauma Center, BG Kliniken Bergmannsheil-Universitätsklinik, Ruhr University, Bochum, Germany.
出版信息
Antimicrob Agents Chemother. 2003 Dec;47(12):3964-6. doi: 10.1128/AAC.47.12.3964-3966.2003.
Abstract
Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of 35 to 124 min after administration of the preoperative dose, except in bone specimens, where they reached 3.9 +/- 2.0 mg/liter.
摘要
通过高效液相色谱法对13例耐甲氧西林葡萄球菌引起的植入物相关感染患者进行了利奈唑胺在骨和关节组织中的渗透研究。术前给药后35至124分钟的采样时间范围内，除骨标本中利奈唑胺平均浓度达到3.9±2.0毫克/升外，感染组织中的利奈唑胺平均浓度均大于10毫克/升。
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