心肌三酰甘油合成与代谢的调节
Regulation of myocardial triacylglycerol synthesis and metabolism.
作者信息
Lewin Tal M, Coleman Rosalind A
机构信息
Department of Nutrition, School of Public Health, University of North Carolina, CB #7400, Pittsboro Street, Chapel Hill, NC 27599, USA.
出版信息
Biochim Biophys Acta. 2003 Nov 15;1634(3):63-75. doi: 10.1016/j.bbalip.2003.09.006.
Studies showing a correlation of excess myocardial triacylglycerol stores with apoptosis, fibrosis, and contractile dysfunction indicate that dysregulation of triacylglycerol metabolism may contribute to cardiac disease. This review covers the regulation of heart triacylglycerol accumulation at the critical control points of fatty acid uptake, enzymes of triacylglycerol synthesis, lipolysis, and lipoprotein secretion. These pathways are discussed in the context of the central role myocardial triacylglycerol plays in cardiac energy metabolism and heart disease.
研究表明，心肌三酰甘油储存过量与细胞凋亡、纤维化及收缩功能障碍相关，这表明三酰甘油代谢失调可能导致心脏疾病。本综述涵盖了在脂肪酸摄取、三酰甘油合成酶、脂解及脂蛋白分泌等关键控制点上心脏三酰甘油积累的调节。这些途径将在心肌三酰甘油在心脏能量代谢和心脏疾病中所起的核心作用的背景下进行讨论。
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