聚酰胺-肽缀合物的合成进展。

Synthetic developments towards PNA-peptide conjugates.

作者信息

de Koning Martijn C, van der Marel Gijs A, Overhand Mark

机构信息

Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands.

出版信息

Curr Opin Chem Biol. 2003 Dec;7(6):734-40. doi: 10.1016/j.cbpa.2003.10.006.

DOI:10.1016/j.cbpa.2003.10.006

PMID:14644183

Abstract

Since the discovery of peptide nucleic acids (PNAs) as DNA mimics in the early 1990s, a tremendous effort has been directed to their application as antisense and antigene probes. With the aim of further enhancing their properties, PNAs have been conjugated to a variety of effector molecules. Among these, small peptide fragments, often derived from functional proteins, are able to convey their specific properties to the conjugate.

摘要

自20世纪90年代初发现肽核酸（PNA）可模拟DNA以来，人们一直致力于将其用作反义探针和反基因探针。为了进一步增强其性能，PNA已与多种效应分子缀合。其中，通常来源于功能蛋白的小肽片段能够将其特定特性传递给缀合物。