Harscher S, Witte O W, Möller U, Bloos G, Pfleiderer S O R, Terborg C
Klinik für Neurologie, Friedrich-Schiller-Universität Jena.
Nervenarzt. 2003 Dec;74(12):1122-6. doi: 10.1007/s00115-003-1581-7.
Sinal thrombosis, intracerebral bleeding, cerebral edema, and cerebral vasospasm are typical neurological complications in pre- and eclampsia. Hemolysis, elevated liver enzyme, and low platelet (HELLP) syndrome is a rare, severe complication of pre-eclampsia. We present the case of a 33-year-old woman with HELLP syndrome. After a cesarean section, generalized epileptic seizure occurred and intubation was necessary due to sustained unconsciousness. Despite magnesium therapy, bilateral hemodynamic ischemic infarctions and narrowing of the circle of Willis were visible on MRI, and vasospasm of all large basal cerebral arteries was confirmed by cerebral angiography and transcranial Doppler sonography. During the following 2 weeks, the cerebral vasospasm resolved with application of high-dose methyl prednisolone and nimodipine. After extubation, the patient initially suffered from mild psychosyndrome and ataxia but recovered completely after 3 months. The HELLP syndrome may be complicated by cerebral vasospasm with subsequent hemodynamic strokes. Combined treatment with magnesium, corticosteroids, and nimodipine can be recommended. In our case, this regimen led to resolution of the cerebral vasospasm and complete clinical recovery.
窦血栓形成、脑出血、脑水肿和脑血管痉挛是先兆子痫和子痫的典型神经并发症。溶血、肝酶升高和血小板减少(HELLP)综合征是先兆子痫的一种罕见的严重并发症。我们报告一例33岁患有HELLP综合征的女性病例。剖宫产术后,患者发生全身性癫痫发作,因持续昏迷而需要插管。尽管进行了镁剂治疗,但磁共振成像(MRI)显示双侧血流动力学性缺血性梗死以及 Willis 环变窄,脑血管造影和经颅多普勒超声检查证实所有大脑基底大动脉均发生血管痉挛。在接下来的2周内,应用大剂量甲基泼尼松龙和尼莫地平后脑血管痉挛得以缓解。拔管后,患者最初出现轻度精神综合征和共济失调,但3个月后完全康复。HELLP综合征可能并发脑血管痉挛及随后的血流动力学性中风。推荐联合使用镁剂、皮质类固醇和尼莫地平进行治疗。在我们的病例中,该治疗方案使脑血管痉挛得到缓解且临床完全康复。