用于类风湿关节炎（RA）免疫治疗的热休克蛋白（HSP）

Heat shock proteins (HSP) for immunotherapy of rheumatoid arthritis (RA).

作者信息

Puga Yung G L, Le T D, Roord S, Prakken B, Albani S

机构信息

Departments of Medicine and Pediatrics, University of California San Diego, 9500 Gilman Jolla, San Diego, CA 92093-0663, USA.

出版信息

Inflamm Res. 2003 Nov;52(11):443-51. doi: 10.1007/s00011-003-1204-6.

DOI:10.1007/s00011-003-1204-6

PMID:14652678

Abstract

Rheumatoid arthritis (RA) is an inflammatory disease that primarily involves the joints and has a worldwide prevalence of about one percent, with a female to male ratio of 3:1. This chapter summarizes some of the recent progress in molecular immunology, and discusses the application of this new knowledge for therapeutic purposes. We focus on our recent experiences and that of others in modulation of antigen specific responses as a tool for manipulating autoimmune inflammation. Particular emphasis is given to the concept of exploiting for therapeutic purposes a natural mechanism of immune regulation. This mechanism is based on sequential cross recognition of bacterial and human derived heat shock protein peptides.

摘要

类风湿性关节炎（RA）是一种主要累及关节的炎症性疾病，全球患病率约为1%，女性与男性的比例为3:1。本章总结了分子免疫学的一些最新进展，并讨论了这些新知识在治疗方面的应用。我们重点关注我们自己以及其他人在调节抗原特异性反应作为控制自身免疫炎症工具方面的最新经验。特别强调了利用免疫调节自然机制用于治疗目的的概念。这种机制基于对细菌和人类来源的热休克蛋白肽的顺序交叉识别。