Nishiumi Noboru, Abe Yoshiyuki, Inoue Yoshimasa, Hatanaka Hiroyuki, Inada Ken-Ichi, Kijima Hiroshi, Yamazaki Hitoshi, Tatematsu Masae, Ueyama Yoshito, Iwasaki Masayuki, Inoue Hiroshi, Nakamura Masato
Department of General Thoracic Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Clin Cancer Res. 2003 Nov 15;9(15):5616-9.
Patients with small adenocarcinoma of the lung (SACL) generally have a good prognosis. However, some SACL cases show lymph node metastasis, with poor prognosis. The expression pattern of 11p15 mucins (clustered on the p15 arm of the chromosome 11) is known to change during carcinogenesis in lung cancer.
We evaluated the expression of the 11p15 mucins (MUC2, MUC5AC, and MUC6) in 79 surgical specimens of SACL cases by immunohistochemical analysis. Lymph node metastasis was estimated by pathological staging.
Six (7.6%) and 11 (13.9%) of the 79 SACL cases showed MUC2 and MUC6 expression, respectively. Three SACL cases showed both MUC2 and MUC6 expression, and a significant correlation was found between MUC2 and MUC6 expression (Fisher's test, P = 0.033). Six (7.6%) SACL cases showed MUC5AC expression. Five of the 6 cases with MUC2 expression and 6 of the 11 cases with MUC6 expression were had lymph node metastasis. SACL cases with MUC2 or MUC6 expression showed a significantly higher incidence of nodal metastasis than those without expression (P < 0.001 and P = 0.006, chi(2) test, respectively). There was no significant correlation between MUC5AC expression and nodal involvement in SACL, whereas three of the six cases with MUC5AC expression showed lymph node metastasis. The SACL cases with MUC2 expression had a significantly poorer prognosis than those without MUC2 expression (P = 0.011, log-rank test).
These results suggest that 11p15 mucins MUC2 and MUC6 are related to lymph node metastasis in SACL.
肺小腺癌（SACL）患者通常预后良好。然而，部分SACL病例会出现淋巴结转移，预后较差。已知11p15黏蛋白（聚集在11号染色体的p15臂上）的表达模式在肺癌发生过程中会发生变化。
我们通过免疫组化分析评估了79例SACL手术标本中11p15黏蛋白（MUC2、MUC5AC和MUC6）的表达。通过病理分期评估淋巴结转移情况。
79例SACL病例中，分别有6例（7.6%）和11例（13.9%）显示MUC2和MUC6表达。3例SACL病例同时显示MUC2和MUC6表达，且MUC2和MUC6表达之间存在显著相关性（Fisher检验，P = 0.033）。6例（7.6%）SACL病例显示MUC5AC表达。6例MUC2表达病例中有5例以及11例MUC6表达病例中有6例发生了淋巴结转移。有MUC2或MUC6表达的SACL病例的淋巴结转移发生率显著高于无表达者（分别为P < 0.001和P = 0.006，卡方检验）。MUC5AC表达与SACL中的淋巴结受累之间无显著相关性，而6例MUC5AC表达病例中有3例发生了淋巴结转移。有MUC2表达的SACL病例的预后明显比无MUC2表达者差（P = 0.011，对数秩检验）。
这些结果表明11p15黏蛋白MUC2和MUC6与SACL中的淋巴结转移有关。
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