头颈部多灶性鳞状细胞癌表现出不同的等位基因缺失模式表型，提示其致癌作用的克隆起源不同。
Multiple squamous cell carcinomas of the head and neck show different phenotypes of allelic loss patterns suggesting different clonal origin of carcinogenesis.
作者信息
Shiga Kiyoto, Ogawa Takenori, Yoshida Fumiaki, Matsuura Kazuto, Tateda Masaru, Saijo Shigeru, Miyagi Taeko, Kobayashi Toshimitsu
机构信息
Department of Otolaryngology, Head and Neck Surgery, Tohoku University School of Medicine, Sendai, Japan.
出版信息
Anticancer Res. 2003 Sep-Oct;23(5A):3911-5.
BACKGROUND
Multiple squamous cell carcinomas in the head and neck are not such a rare phenomenon in patients. To examine if these tumors have the same genetic basis or not, we investigated genetic alterations such as allelic loss in such multiple tumors to see if they showed identical patterns.
MATERIALS AND METHODS
Patterns of the loss of heterozygosity at 3p, 9p and 17p loci were analyzed in multiple head and neck squamous cell carcinomas of the same patient.
RESULTS
Metachronous laryngeal and tongue tumors of a patient were found to have identical patterns of allelic loss, while synchronous tumors of three other patients had different patterns of such loss.
CONCLUSION
Our data support the idea that field carcinogenesis caused by exposure of oral, laryngeal and pharyngeal mucosa to carcinogens may lead to the independent development of synchronous non-related tumors at different sites of the upper aerodigestive tract.
背景
头颈部出现多个鳞状细胞癌在患者中并非罕见现象。为了研究这些肿瘤是否具有相同的遗传基础，我们调查了此类多个肿瘤中的等位基因缺失等基因改变，以观察它们是否呈现相同模式。
材料与方法
对同一患者的多个头颈部鳞状细胞癌中3p、9p和17p位点杂合性缺失模式进行分析。
结果
一名患者的异时性喉癌和舌癌被发现具有相同的等位基因缺失模式，而其他三名患者的同时性肿瘤则具有不同的此类缺失模式。
结论
我们的数据支持这样一种观点，即口腔、喉和咽黏膜暴露于致癌物所导致的场致癌作用可能会在上呼吸道消化道的不同部位独立引发同时性非相关性肿瘤。
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