肥胖引起的脂肪组织炎症变化。
Obesity-induced inflammatory changes in adipose tissue.
作者信息
Wellen Kathryn E, Hotamisligil Gokhan S
机构信息
Department of Genetics and Complex Diseases, Harvard School Of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA.
出版信息
J Clin Invest. 2003 Dec;112(12):1785-8. doi: 10.1172/JCI20514.
Abstract
Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.
摘要
肥胖与慢性低度炎症状态相关。本期《临床研究杂志》的两篇论文（见第1796页和1821页开始的相关文章）报道，肥胖脂肪组织的特征是巨噬细胞浸润，且这些巨噬细胞是该组织炎症的重要来源。这些研究促使人们考虑新的模型，以纳入巨噬细胞在肥胖状态下脂肪组织发生的分子变化中所起的主要作用。
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