Kopp Jürgen, Schwede Torsten
Biozentrum der Universität Basel and Swiss Institute of Bioinformatics, Klingelbergstrasse 50-70, CH 4056 Basel, Switzerland.
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D230-4. doi: 10.1093/nar/gkh008.
The SWISS-MODEL Repository is a database of annotated three-dimensional comparative protein structure models generated by the fully automated homology-modelling pipeline SWISS-MODEL. The Repository currently contains about 300,000 three-dimensional models for sequences from the Swiss-Prot and TrEMBL databases. The content of the Repository is updated on a regular basis incorporating new sequences, taking advantage of new template structures becoming available and reflecting improvements in the underlying modelling algorithms. Each entry consists of one or more three-dimensional protein models, the superposed template structures, the alignments on which the models are based, a summary of the modelling process and a force field based quality assessment. The SWISS-MODEL Repository can be queried via an interactive website at http://swissmodel.expasy. org/repository/. Annotation and cross-linking of the models with other databases, e.g. Swiss-Prot on the ExPASy server, allow for seamless navigation between protein sequence and structure information. The aim of the SWISS-MODEL Repository is to provide access to an up-to-date collection of annotated three-dimensional protein models generated by automated homology modelling, bridging the gap between sequence and structure databases.
SWISS-MODEL 库是一个由全自动同源建模流程 SWISS-MODEL 生成的带注释的三维比较蛋白质结构模型数据库。该库目前包含约 300,000 个针对来自 Swiss-Prot 和 TrEMBL 数据库序列的三维模型。库的内容会定期更新,纳入新序列,利用新出现的模板结构,并反映基础建模算法的改进。每个条目包含一个或多个三维蛋白质模型、叠加的模板结构、模型所基于的比对、建模过程的总结以及基于力场的质量评估。SWISS-MODEL 库可通过交互式网站 http://swissmodel.expasy.org/repository/进行查询。模型与其他数据库(如 ExPASy 服务器上的 Swiss-Prot)的注释和交叉链接允许在蛋白质序列和结构信息之间进行无缝导航。SWISS-MODEL 库的目的是提供对通过自动同源建模生成的最新带注释三维蛋白质模型集合的访问,弥合序列数据库和结构数据库之间的差距。