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单链DNA通过纳米孔的转位:一种主方程方法。

Single stranded DNA translocation through a nanopore: a master equation approach.

作者信息

Flomenbom O, Klafter J

机构信息

School of Chemistry, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel.

出版信息

Phys Rev E Stat Nonlin Soft Matter Phys. 2003 Oct;68(4 Pt 1):041910. doi: 10.1103/PhysRevE.68.041910. Epub 2003 Oct 14.

Abstract

We study voltage driven translocation of a single stranded DNA through a membrane channel. Our model, based on a master equation approach, investigates the probability density function of the translocation times, and shows that it can be either double peaked or mono peaked, depending on the system parameters. We show that the most probable translocation time is proportional to the polymer length, and inversely proportional to the first or second power of the voltage, depending on the initial conditions. The model recovers experimental observations on hetropolymers when using their properties inside the pore, such as stiffness and polymer-pore interaction.

摘要

我们研究了单链DNA通过膜通道的电压驱动转运。我们基于主方程方法的模型研究了转运时间的概率密度函数,并表明根据系统参数,它可以是双峰或单峰的。我们表明,最可能的转运时间与聚合物长度成正比,并且根据初始条件与电压的一次方或二次方成反比。当使用孔内聚合物的性质(如刚度和聚合物-孔相互作用)时,该模型重现了关于杂聚物的实验观察结果。

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