Foss S, Schmidt J R, Andersen T, Rasmussen J J, Damsgaard J, Schaefer K, Munck L K
Hospital Pharmacy, Roskilde County Hospital, 4000 Roskilde, Denmark.
Eur J Clin Pharmacol. 2004 Jan;59(11):841-7. doi: 10.1007/s00228-003-0708-x. Epub 2003 Dec 19.
To analyse congruence on medication throughout patient courses, including an acute admission to a medical department.
A prospective, observational study. Data were collected from patient records in primary health care, hospital departments, from the Health Insurance database and through patient interviews.
Departments of internal medicine, general practice and patients' homes.
Number, type and character of discrepancies between paired sources of information on patient medication at predefined time points throughout the complete patient course. Assessment of likelihood and severity of potential untoward effects of discrepancies.
Data were obtained for 75 of 99 consecutive patients included. Patients stated use of four drugs (median, range 0-17) at admission, five (0-16) at discharge and four (0-15) 1 month after discharge. At admission, 11 patients used no drugs. A median of one (0-20) to three (0-16) discrepancies per patient were identified in seven paired source comparisons with no improvement along patient course. Full agreement throughout the course was found in six patients (8%; 95% confidence interval: 3-17%). No association was found among source discrepancies and number of drugs and age. Of discrepancies, 4-13% were considered serious and likely to cause untoward effects. Discrepancies due to synonymous and analogous drugs accounted for 2-7% of the discrepancies.
Congruence between sources of information on medication throughout patient courses cannot be obtained with separate medication charts. Discrepancies among patient, general practitioner and hospital give rise to a definitive risk of serious untoward effects.
分析患者整个病程中的用药一致性,包括入住内科病房的急性阶段。
一项前瞻性观察性研究。数据从初级卫生保健机构、医院科室的患者记录、健康保险数据库以及通过患者访谈收集。
内科、全科医疗科室及患者家中。
在整个患者病程中预定义时间点上,成对信息源关于患者用药的差异数量、类型和特征。评估差异潜在不良影响的可能性和严重程度。
纳入的99例连续患者中有75例获得了数据。患者入院时称使用4种药物(中位数,范围0 - 17),出院时使用5种(0 - 16),出院后1个月使用4种(0 - 15)。入院时,11例患者未使用药物。在7对信息源比较中,每位患者识别出的差异中位数为1(0 - 20)至3(0 - 16)个,且在患者病程中无改善。6例患者(8%;95%置信区间:3 - 17%)在整个病程中完全一致。未发现信息源差异与药物数量及年龄之间存在关联。差异中,4 - 13%被认为严重且可能导致不良影响。因同义及类似药物导致的差异占差异总数的2 - 7%。
使用单独的用药图表无法在患者整个病程中实现用药信息源之间的一致性。患者、全科医生和医院之间的差异会带来严重不良影响的明确风险。