0.5% 左旋布比卡因与 0.75% 罗哌卡因用于下肢手术的前瞻性、随机、双盲对比研究。

A prospective, randomized, double-blind comparison of epidural levobupivacaine 0.5% with epidural ropivacaine 0.75% for lower limb procedures.

作者信息

Peduto V A, Baroncini S, Montanini S, Proietti R, Rosignoli L, Tufano R, Casati A

机构信息

University of Perugia, Department of Medicina Clinica e Sperimentale, Policlinico Monteluce, Perugia, Italy.

出版信息

Eur J Anaesthesiol. 2003 Dec;20(12):979-83. doi: 10.1017/s0265021503001583.

DOI:10.1017/s0265021503001583

PMID:14690101

Abstract

BACKGROUND AND OBJECTIVE

This prospective, randomized, observer-blinded study compared onset time and duration of epidural anaesthesia produced by with levobupivacaine and ropivacaine for lower limb surgery.

METHODS

ASA I-III adult patients undergoing elective lower limb procedures were randomized to receive epidural levobupivacaine 0.5% 15 mL (n = 30) or epidural ropivacaine 0.75% 15 mL (n = 35). A blinded observer evaluated onset time and regression of motor and sensory block, and intraoperative needs for fentanyl supplementation (0.1 mg intravenously).

RESULTS

With levobupivacaine, onset time was 29 +/- 24 min, with ropivacaine it was 25 +/- 22 min (P = 0.41). Complete resolution of motor block required 105 +/- 63 min with levobupivacaine and 95 +/- 48 min with ropivacaine (P = 0.86). The time for regression of sensory block to T12 was 185 +/- 77 min with levobupivacaine and 201 +/- 75 min with ropivacaine (P = 0.46). Analgesic supplementation was required in one patient receiving levobupivacaine (3.5%) and in two patients receiving ropivacaine (5.7%) (P = 0.99).

CONCLUSIONS

In adults undergoing lower limb surgery, levobupivacaine 0.5% 15 mL produces an epidural block with the same clinical profile as ropivacaine 0.75% 15 mL.

摘要

背景与目的

本前瞻性、随机、观察者盲法研究比较了左旋布比卡因和罗哌卡因用于下肢手术时硬膜外麻醉的起效时间和持续时间。

方法

将接受择期下肢手术的ASA I - III级成年患者随机分为两组，一组接受15毫升0.5%左旋布比卡因硬膜外注射（n = 30），另一组接受15毫升0.75%罗哌卡因硬膜外注射（n = 35）。由一位盲法观察者评估运动和感觉阻滞的起效时间及消退情况，以及术中芬太尼补充需求（静脉注射0.1毫克）。

结果

使用左旋布比卡因时，起效时间为29±24分钟，使用罗哌卡因时为25±22分钟（P = 0.41）。左旋布比卡因使运动阻滞完全消退需要105±63分钟，罗哌卡因需要95±48分钟（P = 0.86）。感觉阻滞消退至T12水平，左旋布比卡因需要185±77分钟，罗哌卡因需要201±75分钟（P = 0.46）。接受左旋布比卡因的1例患者（3.5%）和接受罗哌卡因的2例患者（5.7%）需要镇痛补充（P = 0.99）。