Raftopoulou Myrto, Hall Alan
MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, Cancer Research UK Oncogene and Signal Transduction Group, University College London, London WC1E 6BT, UK.
Dev Biol. 2004 Jan 1;265(1):23-32. doi: 10.1016/j.ydbio.2003.06.003.
Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse functions, Rho GTPases influence many aspects of cell behavior. This review will focus specifically on their role in cell migration.
Rho GTP酶控制着将细胞表面受体与多种细胞内反应相连接的信号转导通路。它们最为人所知的是作为肌动蛋白细胞骨架的调节因子，但除此之外，它们还控制细胞极性、基因表达、微管动力学和囊泡运输。通过这些多样的功能，Rho GTP酶影响细胞行为的许多方面。本综述将特别聚焦于它们在细胞迁移中的作用。
