女性对烟草致癌物的易感性。
Women's susceptibility to tobacco carcinogens.
作者信息
Henschke Claudia I, Miettinen Olli S
机构信息
Department of Radiology, New York Presbyterian Hospital, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY, USA.
出版信息
Lung Cancer. 2004 Jan;43(1):1-5. doi: 10.1016/j.lungcan.2003.08.024.
STUDY OBJECTIVES
To assess lung cancer risk of smoking women relative to that of equally smoking men.
METHODS
The study base was constituted by baseline CT screenings for lung cancer on 1202 women and 1288 men, at least 40 years of age and with at least 10 pack-years of cigarette smoking. The prevalence-odds (incidence-density) ratio contrasting women with men was calculated. Confoundings by age and the particulars of smoking history were controlled in logistic regression analysis.
RESULTS
For the prevalence-odds ratio contrasting women with men, upon control of age and smoking history, the point estimate was 2.7 and the 95% interval estimate 1.6-4.7. The diagnosed cancers were of equally 'aggressive' types between the two genders.
CONCLUSIONS
At variance with evidence from cohort studies, this evidence from a screening experience calls for further consideration of the hypothesis that women are more susceptible to tobacco carcinogens than are men.
研究目的
评估吸烟女性相对于同等吸烟量男性的肺癌风险。
方法
研究对象为1202名女性和1288名男性，年龄至少40岁，吸烟史至少10包年，基于他们进行肺癌的基线CT筛查。计算女性与男性对比的患病率比值（发病率密度比）。在逻辑回归分析中控制年龄和吸烟史的混杂因素。
结果
对于女性与男性对比的患病率比值，在控制年龄和吸烟史后，点估计值为2.7，95%区间估计为1.6 - 4.7。两性诊断出的癌症类型同样具有“侵袭性”。
结论
与队列研究的证据不同，来自筛查经验的这一证据要求进一步考虑女性比男性更容易受到烟草致癌物影响这一假设。
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