[Effects of L-arginine on the function of platelet aggregation during hepatic ischemia/reperfusion injury].

OBJECTIVE

To explore the effects of L-arginine (L-Arg) on the function of platelet aggregation during hepatic ischemia-reperfusion injury (HIRI).

METHODS

The changes in maximum aggregating rate of circulating platelets (Pt(max)), its maximum aggregating time (PtT) as well as its aggregating slopes (PtS) were measured. Effects of L-Arg on those parameters were observed during HIRI in 20 rabbits and 18 patients who were scheduled for elective hepatic surgery.

RESULTS

Pt max and PtS all increased significantly (P<0.05 and P<0.01), while PtT decreased remarkably (both P<0.05) during HIRI of rabbits and patients. After treatment with L-Arg, the abnormal changes of parameters as above were all alleviated remarkably (P<0.05 and P<0.01).

CONCLUSION

It is indicated that L-Arg can effectively regulate the function of platelet aggregation during HIRI.