蛋白质和RNA的核运输途径。

Pathways for the nuclear transport of proteins and RNAs.

作者信息

Goldfarb D, Michaud N

机构信息

Department of Biology, University of Rochester, Rochester, NY 14627, USA.

出版信息

Trends Cell Biol. 1991 Jul;1(1):20-4. doi: 10.1016/0962-8924(91)90065-h.

DOI:10.1016/0962-8924(91)90065-h

PMID:14731805

Abstract

The nuclear pore complex catalyses the import and export of both proteins and RNAs. The molecular mechanisms of RNA and protein translocation through the nuclear pore are likely to be similar; however, their signals and targeting apparatus may differ. Recent insights into RNA transport have come from studies of kinetic control mechanisms and the preconditions for translocation that include processing, RNP assembly, and a targeting function for 5' caps.

摘要

核孔复合体催化蛋白质和RNA的输入与输出。RNA和蛋白质通过核孔进行转运的分子机制可能相似；然而，它们的信号和靶向装置可能有所不同。近期对RNA转运的深入了解来自对动力学控制机制以及转运前提条件的研究，这些前提条件包括加工、核糖核蛋白组装以及5'帽的靶向功能。