Ishikawa Masayoshi, Maeda Katsuhiro, Mitsutsuji Yuuki, Yashima Eiji
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan.
J Am Chem Soc. 2004 Jan 28;126(3):732-3. doi: 10.1021/ja039279k.
We have found an unprecedented memory of macromolecular helicity induced in an achiral sodium salt of poly(4-carboxyphenyl isocyanide) (poly-1-Na). Poly-1-Na folds into a one-handed helix through configurational isomerization around the C=N backbones by interactions with optically active amines in water. The helix remains when the optically active amines are completely removed, and further modifications of the side group to carboxy and esters can be possible without loss of the macromolecular helicity memory.
我们发现聚（4-羧基苯基异氰化物）（聚-1-Na）的一种非手性钠盐中诱导出了前所未有的大分子螺旋记忆。在水中，聚-1-Na通过与旋光性胺相互作用，围绕C=N主链进行构型异构化，折叠成单手螺旋。当旋光性胺完全去除后，螺旋结构依然保留，并且侧基进一步修饰为羧基和酯基时，大分子螺旋记忆也不会丧失。
