Papavramidis Spiros T, Eleftheriadis Efthymios E, Papavramidis Theodossis S, Kotzampassi Katerina E, Gamvros Orestis G
Aristotelian University of Thessaloniki, Department of Surgery III, AHEPA Hospital, Thessaloniki, Macedonia, Greece.
Gastrointest Endosc. 2004 Feb;59(2):296-300. doi: 10.1016/s0016-5107(03)02545-8.
Gastrocutaneous fistula is an uncommon and difficult to treat complication that occurs in 0.5% to 3.9% of patients who undergo gastric surgery. Sepsis usually follows, and, when it is not managed effectively, the associated mortality rate can be as high as 85%. A fibrin sealant was used to endoscopically manage gastrocutaneous fistulas that developed in 3 morbidly obese patients after bariatric surgery.
Two of 14 (14.29%) patients who underwent vertical gastroplasty (MacLean procedure) developed a non-healing gastrocutaneous fistula. In addition, one of 24 (4.17%) patients who had a biliopancreatic diversion with preservation of pylorus developed a gastrocutaneous fistula. Endoscopic application of a fibrin sealant was performed under direct vision via a double-lumen catheter passed through a forward-viewing endoscope.
Treatment was successful in all patients after one or more endoscopic sessions in which the fibrin sealant was applied; no evidence of fistula was found at follow-up endoscopy.
Endoscopic closure of gastrocutaneous fistula with human fibrin tissue sealant is simple, safe, and effective, and, in some cases, can be life-saving. Endoscopic application of fibrin sealant should be considered a therapeutic option for treatment of gastrocutaneous fistula that develops after bariatric surgery.
胃皮肤瘘是一种罕见且难以治疗的并发症,在接受胃部手术的患者中发生率为0.5%至3.9%。通常会随之发生脓毒症,若未得到有效处理,相关死亡率可高达85%。一种纤维蛋白密封剂被用于内镜治疗3例肥胖症患者在减肥手术后出现的胃皮肤瘘。
14例接受垂直胃成形术(麦克林手术)的患者中有2例(14.29%)出现不愈合的胃皮肤瘘。此外,24例接受保留幽门的胆胰转流术的患者中有1例(4.17%)出现胃皮肤瘘。通过经前视内镜插入的双腔导管在直视下进行纤维蛋白密封剂的内镜应用。
在进行了一次或多次应用纤维蛋白密封剂的内镜治疗后,所有患者的治疗均获成功;随访内镜检查未发现瘘的迹象。
用人纤维蛋白组织密封剂内镜闭合胃皮肤瘘简单、安全且有效,在某些情况下可挽救生命。纤维蛋白密封剂的内镜应用应被视为减肥手术后发生的胃皮肤瘘的一种治疗选择。