急性给予选择性5-羟色胺再摄取抑制剂后大脑γ-氨基丁酸浓度升高。
Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor.
作者信息
Bhagwagar Zubin, Wylezinska Marzena, Taylor Matthew, Jezzard Peter, Matthews Paul M, Cowen Philip J
机构信息
University Department of Psychiatry, Warneford Hospital, Oxford, UK.
出版信息
Am J Psychiatry. 2004 Feb;161(2):368-70. doi: 10.1176/appi.ajp.161.2.368.
OBJECTIVE
The authors used magnetic resonance spectroscopy (MRS) to assess the effect of acute administration of the selective serotonin reuptake inhibitor (SSRI) citalopram on cortical levels of gamma-aminobutyric acid (GABA).
METHOD
Ten healthy volunteers received either intravenous citalopram (10 mg) or saline in a randomized, double-blind, crossover design. The occipital GABA/creatine ratio was measured with a proton MR spectral editing technique.
RESULTS
In comparison with saline, citalopram produced a mean increase of 35% in relative brain GABA concentration in the occipital cortex.
CONCLUSIONS
These findings extend previous work showing that SSRI treatment increases cortical GABA in depressed patients and suggest that this results from an action of SSRIs on GABA neurons rather than as a secondary consequence of mood improvement.
目的
作者使用磁共振波谱（MRS）来评估选择性5-羟色胺再摄取抑制剂（SSRI）西酞普兰急性给药对γ-氨基丁酸（GABA）皮质水平的影响。
方法
10名健康志愿者以随机、双盲、交叉设计接受静脉注射西酞普兰（10毫克）或生理盐水。采用质子磁共振波谱编辑技术测量枕叶GABA/肌酸比值。
结果
与生理盐水相比，西酞普兰使枕叶皮质相对脑GABA浓度平均增加35%。
结论
这些发现扩展了先前的研究工作，表明SSRI治疗可增加抑郁症患者的皮质GABA，并提示这是SSRI作用于GABA神经元的结果，而非情绪改善的继发后果。
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