Ozçelik Mehmet Faik, Pekmezci Salih, Saribeyoğlu Kaya, Unal Ethem, Gümüştaş Koray, Doğusoy Gülen
Department of General Surgery, Istanbul University, Cerrahpasa Medical Faculty, 34622 Istanbul, Turkey.
Am J Surg. 2004 Feb;187(2):257-60. doi: 10.1016/j.amjsurg.2003.11.008.
To assess the effects of halofuginone, a specific inhibitor of synthesis of collagen type 1, which is the major constituent of fibrosis, on esophageal stricture formation due to caustic ingestion.
Sixty rats were divided into four equal groups: control group; sham laparotomy group; caustic injury without treatment group; caustic injury with halofuginone treatment group. Caustic injuries were done by 50% sodium hydroxide. Halofuginone was administered by the first postoperative day. All animals were sacrificed on day 21; and the results were evaluated by hydroxyproline levels, stenosis index, lumen diameter, histopathological evaluation, wall thickness, and animal weights.
Mortality differences were significant comparing group 3 with group 1 and 2 (P = 0.006) and group 4 (P = 0.03). According to hydroxyproline levels, the differences are significantly higher (P <0.001) comparing group 3 with group 1, 2, and 4. The P value was considered significant in all other parameters (P <0.001) for all the groups but group 1 versus group 2 (P >0.05).
Halofuginone, a specific inhibitor of collagen type 1 synthesis, significantly reduced esophageal stricture occurrence.
评估卤夫酮（一种I型胶原蛋白合成的特异性抑制剂，I型胶原蛋白是纤维化的主要成分）对因腐蚀性物质摄入导致的食管狭窄形成的影响。
将60只大鼠分为四组，每组数量相等：对照组；假手术组；腐蚀性损伤未治疗组；腐蚀性损伤卤夫酮治疗组。用50%氢氧化钠造成腐蚀性损伤。术后第一天开始给予卤夫酮。所有动物在第21天处死；通过羟脯氨酸水平、狭窄指数、管腔直径、组织病理学评估、壁厚和动物体重评估结果。
比较第3组与第1组和第2组（P = 0.006）以及第4组（P = 0.03），死亡率差异有统计学意义。根据羟脯氨酸水平，比较第3组与第1组、第2组和第4组，差异显著更高（P <0.001）。除第1组与第2组外（P >0.05），所有组在所有其他参数中的P值均具有统计学意义（P <0.001）。
卤夫酮，一种I型胶原蛋白合成的特异性抑制剂，显著降低了食管狭窄的发生率。
