苯妥英钠和甲苯磺丁脲在人体代谢中的共同调节。
Co-regulation of phenytoin and tolbutamide metabolism in humans.
作者信息
Tassaneeyakul W, Veronese M E, Birkett D J, Doecke C J, McManus M E, Sansom L N, Miners J O
机构信息
Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, South Australia.
出版信息
Br J Clin Pharmacol. 1992 Dec;34(6):494-8.
Abstract
- The disposition of phenytoin and tolbutamide was compared in eighteen healthy young adults separately administered single therapeutic doses (sodium phenytoin 300 mg, tolbutamide 500 mg) of the two drugs. 2. Within the group, ratios of ranges of total and unbound areas under the plasma concentration-time curves were similar for both drugs. 3. There were significant (P < 0.001) correlations between total (r = 0.88) and unbound (r = 0.86) areas under the plasma phenytoin and tolbutamide concentration-time curves. 4. The results are consistent with the involvement of the same cytochrome P-450 isoenzyme(s) in the metabolism of tolbutamide and phenytoin.
摘要
- 在18名健康年轻成年人中分别给予苯妥英钠和甲苯磺丁脲单次治疗剂量（苯妥英钠300mg，甲苯磺丁脲500mg），比较了这两种药物的处置情况。2. 在该组内，两种药物血浆浓度-时间曲线下总浓度和游离浓度范围的比值相似。3. 苯妥英钠和甲苯磺丁脲血浆浓度-时间曲线下的总浓度（r = 0.88）和游离浓度（r = 0.86）之间存在显著（P < 0.001）相关性。4. 结果表明甲苯磺丁脲和苯妥英钠的代谢涉及相同的细胞色素P-450同工酶。
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