内质网中蛋白质折叠对mRNA翻译的调控。

Regulation of mRNA translation by protein folding in the endoplasmic reticulum.

作者信息

Kaufman Randal J

机构信息

Department of Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0650, USA.

出版信息

Trends Biochem Sci. 2004 Mar;29(3):152-8. doi: 10.1016/j.tibs.2004.01.004.

DOI:10.1016/j.tibs.2004.01.004

PMID:15003273

Abstract

The process of protein secretion is intimately linked to the rate and potential of proper folding and assembly of secretory proteins. The efficiency of protein folding is communicated to the cytoplasm via several signal transduction pathways. This regulates the rate of polypeptide chain synthesis and induction of genes encoding functions that reduce protein-folding load on the endoplasmic reticulum (ER). This review summarizes recent insights into the mechanisms that couple protein translation with protein folding in the ER.

摘要

蛋白质分泌过程与分泌蛋白正确折叠和组装的速率及潜力密切相关。蛋白质折叠的效率通过多种信号转导途径传递到细胞质中。这调节了多肽链合成的速率以及编码可减轻内质网（ER）蛋白质折叠负荷功能的基因的诱导。本综述总结了关于内质网中蛋白质翻译与蛋白质折叠偶联机制的最新见解。