乳腺珠蛋白：一种乳腺癌的候选诊断标志物。

Mammaglobin: a candidate diagnostic marker for breast cancer.

作者信息

Zehentner Barbara K, Carter Darrick

机构信息

Department of Antigen Discovery, Corixa Corporation, Seattle, WA 98104, USA.

出版信息

Clin Biochem. 2004 Apr;37(4):249-57. doi: 10.1016/j.clinbiochem.2003.11.005.

DOI:10.1016/j.clinbiochem.2003.11.005

PMID:15003725

Abstract

Mammaglobin, known for its mammary tissue specificity, has been discussed as a promising diagnostic marker in breast cancer for almost 10 years. In particular, the application of mammaglobin RT-PCR to detect disseminated breast cancer cells has been reported. More than 25 publications evaluate the detection of mammaglobin mRNA in lymph node, blood, and bone marrow specimens of breast cancer patients. Recently, structural details about the mammaglobin complex have been discovered, and these findings can be implemented to optimize detection of the secreted protein. This review summarizes the findings of almost 50 published studies and the current knowledge about the diagnostic utility of mammaglobin.

摘要

乳腺珠蛋白以其乳腺组织特异性而闻名，近十年来一直被视为一种很有前景的乳腺癌诊断标志物。特别是，已有报道应用乳腺珠蛋白逆转录聚合酶链反应（RT-PCR）检测播散性乳腺癌细胞。超过25篇出版物评估了在乳腺癌患者的淋巴结、血液和骨髓标本中检测乳腺珠蛋白mRNA的情况。最近，关于乳腺珠蛋白复合物的结构细节已被发现，这些发现可用于优化对分泌蛋白的检测。这篇综述总结了近50项已发表研究的结果以及目前关于乳腺珠蛋白诊断效用的知识。