通过超高速光谱域光学相干断层扫描进行人体视网膜活体成像。

In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography.

作者信息

Nassif Nader, Cense Barry, Park B Hyle, Yun Seok H, Chen Teresa C, Bouma Brett E, Tearney Guillermo J, de Boer Johannes F

机构信息

Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA.

出版信息

Opt Lett. 2004 Mar 1;29(5):480-2. doi: 10.1364/ol.29.000480.

DOI:10.1364/ol.29.000480

PMID:15005199

Abstract

An ultrahigh-speed spectral domain optical coherence tomography (SD-OCT) system is presented that achieves acquisition rates of 29,300 depth profiles/s. The sensitivity of SD-OCT and time domain OCT (TD-OCT) are experimentally compared, demonstrating a 21.7-dB improvement of SD-OCT over TD-OCT. In vivo images of the human retina are presented, demonstrating the ability to acquire high-quality structural images with an axial resolution of 6 microm at ultrahigh speed and with an ocular exposure level of less than 600 microW.

摘要

本文介绍了一种超高速光谱域光学相干断层扫描（SD-OCT）系统，其采集速率可达29300深度剖面/秒。通过实验比较了SD-OCT和时域光学相干断层扫描（TD-OCT）的灵敏度，结果表明SD-OCT比TD-OCT的灵敏度提高了21.7分贝。文中展示了人类视网膜的体内图像，证明了该系统能够以超高速、小于600微瓦的眼部曝光水平，获得轴向分辨率为6微米的高质量结构图像。