抗精神病药物在普通住院患者治疗中的超说明书用药及非经典处方情况
Off-label and non-classical prescriptions of antipsychotic agents in ordinary in-patient practice.
作者信息
Barbui C, Ciuna A, Nosé M, Patten S B, Stegagno M, Burti L, Amaddeo F, Tansella M
机构信息
Department of Medicine and Public Health, Section of Psychiatry, University of Verona, Ospedale Policlinico, 37134 Verona, Italy.
出版信息
Acta Psychiatr Scand. 2004 Apr;109(4):275-8. doi: 10.1111/j.1600-0447.2003.00283.x.
OBJECTIVE
To estimate the proportion of off-label prescriptions of antipsychotics (APs) in ordinary in-patient practice.
METHOD
From the South-Verona Psychiatric Case Register all admissions to the in-patient unit during 2001-02 were extracted. Prescriptions of APs were defined off-label when dispensed outside the licensed indications. In addition, the proportion of "non-classical prescriptions" was calculated.
RESULTS
During the 2 years surveyed AP agents were prescribed in 311 cases. Nearly 50% of second-generation AP prescriptions were for an off-label indication. In contrast, <15% of first-generation AP prescriptions were for an off-label indication. About 30% of first- and second-generation agents were prescribed for a non-classical indication.
CONCLUSION
Approved labels for second-generation AP agents cover a much narrower range of indications than any of the first-generation agents, and this explains the higher proportion of off-label prescriptions. In contrast, the everyday use of first- and second-generation APs cover a similar range of clinical indications.
目的
评估普通住院患者中抗精神病药物（APs）的超说明书用药比例。
方法
从南维罗纳精神病病例登记册中提取2001 - 2002年期间所有住院患者的信息。当APs的处方用于超出许可适应症范围时，被定义为超说明书用药。此外，还计算了“非经典处方”的比例。
结果
在调查的2年中，有311例患者开具了APs药物。近50%的第二代APs处方用于超说明书适应症。相比之下，第一代APs处方用于超说明书适应症的比例不到15%。约30%的第一代和第二代药物被用于非经典适应症。
结论
第二代APs药物的批准适应症范围比任何第一代药物都窄得多，这解释了超说明书用药比例较高的原因。相比之下，第一代和第二代APs的日常使用涵盖了相似的临床适应症范围。
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